People against the common male infertility factor is familiar with, and no sperm disease and less idiopathic, weak, lopsided sperm the cause of disease know enough. In recent years, through the cell and molecular biology technology found that the cause of this kind of patients often is the gene mutation and chromosome aberration, including chromosome quantity, hence this kind of disease called the hereditary disease bo sperm happen this disease incidence is increasing year by year, is now 30%.
Sperm happen genetic disease can be divided into two kinds, one kind is The Times body sex chromosomes, another kind is genetic mutations. Both born in pure obstacles. The second category also includes three kind of situation that control of the genetic mutations occur sperm specific, regulation, the development of the genetic mutation and somatic autosomal genetic mutations.
The Times body sex chromosomes refers to the number of chromosomes, abnormal cells imbalance or abnormal chromosomes structure. Whether The Times body sex chromosomes sex or autosomal The Times body sex, which can lead to life essence obstacle, cause male infertility.
Caused by gene mutations sperm happen is to point to some obstacles do not affect chromosomal structures and only on more reliable molecular biology technology to determine the genetic mutations, such as point mutations, micro missing or rearrange etc caused by the sperm happen obstacles.
Therefore, many reason unknown male infertility and chromosome and abnormal gene relevant. This for clinical diagnosis of male infertility pointed out the direction, suggest that for every male infertility patients have to carry out strict genetic counseling and conventional chromosome analysis. At the same time, the auxiliary reproductive technology before for the fine to strict genetics inspection to prevent a genetic defect of the union of sperm and egg and several kinds of genetic defect to the next generation.
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